시그니처 균주
BIFIDOBACTERIUM ANIMALIS SSP. LACTIS B420™
Grant JR, Stothard P. The CGView Server: a comparative genomics tool for circular genomes. Nucleic Acids Res. 2008;36:W181-W184.
소개
B. lactis B420™은 16개의 인체적용시험을 포함하여, 60개 이상의 과학 연구들을 통해 확인되어 왔습니다. 이것은 장을 통과하여 생존한다는 것이 인체적용시험에서 확인되었으며, In vitro 연구들을 통해 인간 장 점액에 대한 뛰어난 접착력을 보여주었습니다.1-3 B420™의 주요 건강 기능은 체중과 신진대사 관리이며, 이러한 기능은 장 장벽 온전성(intestinal barrier integrity)을 지원하는 능력과 관련된 것으로 여겨지고 있습니다.4-6 이 외에, B420™ 섭취에 따라 날씬하고 건강한 체중과 연관된 세균 종, Akkermansia muciniphila가 장에서 풍부하게 증가되었습니다.7 B420™은 인체적용시험과 동물 실험 모두 체중 관리를 지원하고, 더 나은 신진대사를 유도하는 실증적 지표가 확인되었습니다.8-10
건강 기능 분야
건강 기능 분야
지원되는 함량
지원되는 함량
10 billion B420™
제품 기능성 연구들을 통한 41개의 in vitro 연구
참고문헌:
1. Klein A, Friedrich U, Vogelsang H, Jahreis G. Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC B-420 modulate unspecific cellular immune response in healthy adults. Eur J Clin Nutr. 2008;62:584-659. 2. Kok RG, de Waal A, Schut F, et al. Specific detection and analysis of a probiotic Bifidobacterium strain in infant feces. Appl Environ Microbiol. 1996;62:3668-3672. 3. Collado MC, Meriluoto J, Salminen S. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol. 2007;45: 454-460. 4. Lindfors K, Blomqvist T, Juuti-Uusitalo K, et al. Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clin Exp Immunol. 2008;152:552-558. 5. Putaala H, Salusjarvi T, Nordstrom M, et al. Effect of four probiotic strains and Escherichia coli O157:H7 on tight junction integrity and cyclo-oxygenase expression. Res Microbiol. 2008;159;692-698. 6. Mokkala K, Laitinen K, Roytio H. Bifidobacterium lactis B-420 and fish oil enhance intestinal epithelial integrity in Caco-2 cells. Nutr Res. 2016;36:246-252. 7. Hibberd AA, Yde CC, Ziegler ML, et al. Probiotic or synbiotic alters the gut microbiota and metabolism in a randomised controlled trial of weight management in overweight adults. Beneficial Microbes. 2018;1-16. 8. Stenman LK, Lehtinen MJ, Meland N, et al. Probiotic with or without fiber controls body fat mass, associated with serum zonulin, in overweight and obese adults—Randomized controlled trial. EBioMedicine. 2016. Nov;13:190–200. http://dx.doi.org/10.1016/j.ebiom.2016.10.036. 9. Stenman LK, Waget A, Garret C, et al. Probiotic BB-420 and prebiotic polydextrose improve efficacy of antidiabetic drugs in mice. Diabetology & Metabolic Syndrome. 2015;7:75. 10. Stenman LK, Waget A, Garret C, et al. Potential probiotic Bifidobacterium animalis ssp. lactis B-420 prevents weight gain and glucose intolerance in diet-induced obese mice. Beneficial Microbes. 2014;5:437-445.
1. Klein A, Friedrich U, Vogelsang H, Jahreis G. Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC B-420 modulate unspecific cellular immune response in healthy adults. Eur J Clin Nutr. 2008;62:584-659. 2. Kok RG, de Waal A, Schut F, et al. Specific detection and analysis of a probiotic Bifidobacterium strain in infant feces. Appl Environ Microbiol. 1996;62:3668-3672. 3. Collado MC, Meriluoto J, Salminen S. Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol. 2007;45: 454-460. 4. Lindfors K, Blomqvist T, Juuti-Uusitalo K, et al. Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clin Exp Immunol. 2008;152:552-558. 5. Putaala H, Salusjarvi T, Nordstrom M, et al. Effect of four probiotic strains and Escherichia coli O157:H7 on tight junction integrity and cyclo-oxygenase expression. Res Microbiol. 2008;159;692-698. 6. Mokkala K, Laitinen K, Roytio H. Bifidobacterium lactis B-420 and fish oil enhance intestinal epithelial integrity in Caco-2 cells. Nutr Res. 2016;36:246-252. 7. Hibberd AA, Yde CC, Ziegler ML, et al. Probiotic or synbiotic alters the gut microbiota and metabolism in a randomised controlled trial of weight management in overweight adults. Beneficial Microbes. 2018;1-16. 8. Stenman LK, Lehtinen MJ, Meland N, et al. Probiotic with or without fiber controls body fat mass, associated with serum zonulin, in overweight and obese adults—Randomized controlled trial. EBioMedicine. 2016. Nov;13:190–200. http://dx.doi.org/10.1016/j.ebiom.2016.10.036. 9. Stenman LK, Waget A, Garret C, et al. Probiotic BB-420 and prebiotic polydextrose improve efficacy of antidiabetic drugs in mice. Diabetology & Metabolic Syndrome. 2015;7:75. 10. Stenman LK, Waget A, Garret C, et al. Potential probiotic Bifidobacterium animalis ssp. lactis B-420 prevents weight gain and glucose intolerance in diet-induced obese mice. Beneficial Microbes. 2014;5:437-445.
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